2023

• Fan LC, McConn K, Plataki M, Kenny S, Williams NC, Kim K, Quirke JA, Chen Y, Sauler M, Möbius ME, Chung KP, Area Gomez E, Choi AM, Xu JF, Cloonan SM. Alveolar type II epithelial cell FASN maintains lipid homeostasis in experimental COPD. JCI Insight. 2023 Aug 22;8(16):e163403

• Cuevas Ocaña S, El-Merhie N, Kuipers ME, Lehmann M, Enes SR, Voss C, Dean LSN, Loxham M, Boots AW, Cloonan SM, Greene CM, Heijink IH, Joannes A, Mailleux AA, Mansouri N, Reynaert NL, van der Does AM, Wagner DE, Ubags N. ERS International Congress 2022: highlights from the Basic and Translational Science Assembly.ERJ Open Res. 2023 Apr 17;9(2):00561-2022

• Kim K, Zhang WZ, Kikkers SA, O'Beirne SL, Strulovici-Barel Y, Kaner RJ, Crystal RG, Cloonan SM. Use of the Iron Chelator Deferiprone to Restore Function in BAL Fluid Macrophages in Smoking and Chronic Obstructive Pulmonary Disease. Am J Respir Cell Mol Biol. 2023 Apr;68(4):458-462

• Cloonan SM."KEAP"ing Alveolar Macrophage Mitochondria Content in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2023 Apr 15;207(8):962-964

• Faherty L, Kenny S, Cloonan SM. Iron and mitochondria in the susceptibility, pathogenesis and progression of COPD. Clin Sci (Lond). 2023 Feb 14;137(3):219-237.

• Salih MM, Robinson EK, Malekos E, Perez E, Capili A, Kim K, Zhang WZ, Cloonan SM, Carpenter S. LincRNA-Cox2 Regulates Smoke-induced Inflammation in Murine Macrophages. Am J Respir Cell Mol Biol. 2023 May;68(5):511-522.

• Cloonan SM. OLA1 Phosphorylation: A Distress Signal from Damaged Endothelial Mitochondria?Am J Respir Cell Mol Biol. 2023 Apr;68(4):347-348.

2022

• Cui Y, Gutierrez S, Ariai S, Öberg L, Thörn K, Gehrmann U, Cloonan SM, Naessens T, Olsson H. Non-heme iron overload impairs monocyte to macrophage differentiation via mitochondrial oxidative stress. Front Immunol. 2022 Oct 21;13:998059.

• Sayles NM, Southwell N, McAvoy K, Kim K, Pesini A, Anderson CJ, Quinzii C, Cloonan S, Kawamata H, Manfredi G. Mutant CHCHD10 causes an extensive metabolic rewiring that precedes OXPHOS dysfunction in a murine model of mitochondrial cardiomyopathy. Cell Rep. 2022 Mar 8;38(10):110475.

• Williams NC, Ryan DG, Costa ASH, Mills EL, Jedrychowski MP, Cloonan SM, Frezza C, O'Neill LA. Signaling metabolite L-2-hydroxyglutarate activates the transcription factor HIF-1α in lipopolysaccharide-activated macrophages. J Biol Chem. 2022 Feb;298(2):101501.

2021

• Ramchandani D, Berisa M, Tavarez DA, Li Z, Miele M, Bai Y, Lee SB, Ban Y, Dephoure N, Hendrickson RC, Cloonan SM, Gao D, Cross JR, Vahdat LT, Mittal V. Copper depletion modulates mitochondrial oxidative phosphorylation to impair triple negative breast cancer metastasis. Nat Commun. 2021 Dec 15;12(1):7311.

• Hisata S, Racanelli AC, Kermani P, Schreiner R, Houghton S, Palikuqi B, Kunar B, Zhou A, McConn K, Capili A, Redmond D, Nolan DJ, Ginsberg M, Ding BS, Martinez FJ, Scandura JM, Cloonan SM, Rafii S, Choi AMK. Reversal of emphysema by restoration of pulmonary endothelial cells. J Exp Med. 2021 Aug 2;218(8):e20200938.

• Robinson EK, Jagannatha P, Covarrubias S, Cattle M, Smaliy V, Safavi R, Shapleigh B, Abu-Shumays R, Jain M, Cloonan SM, Akeson M, Brooks AN, Carpenter S.Inflammation drives alternative first exon usage to regulate immune genes including a novel iron regulated isoform of Aim2. Elife. 2021 May 28;10:e69431. doi: 10.7554/eLife.69431.

• Healy C, Munoz-Wolf N, Strydom J, Faherty L, Williams NC, Kenny S, Donnelly SC, Cloonan SM. Nutritional immunity: the impact of metals on lung immune cells and the airway microbiome during chronic respiratory disease. Respir Res. 2021 Apr 29;22(1):133.

• Zhang WZ, Hoffman KL, Schiffer KT, Oromendia C, Rice MC, Barjaktarevic I, Peters SP, Putcha N, Bowler RP, Wells JM, Couper DJ, Labaki WW, Curtis JL, Han MK, Paine R 3rd, Woodruff PG, Criner GJ, Hansel NN, Diaz I, Ballman KV, Nakahira K, Choi ME, Martinez FJ, Choi AMK, Cloonan SM. Association of plasma mitochondrial DNA with COPD severity and progression in the SPIROMICS cohort. Respir Res. 2021 Apr 26;22(1):126.

2020

• Cloonan SM, Kim K, Esteves P, Trian T, Barnes PJ. Mitochondrial dysfunction in lung ageing and disease.

  Eur Respir Rev. 2020 Oct 15;29(157):200165.

• Perez E, Baker JR, Di Giandomenico S, Kermani P, Parker J, Kim K, Yang J, Barnes PJ, Vaulont S, Scandura JM, Donnelly LE, Stout-Delgado H, Cloonan SM. Hepcidin Is Essential for Alveolar Macrophage Function and Is Disrupted by Smoke in a Murine Chronic Obstructive Pulmonary Disease Model. J Immunol. 2020 Sep 21:ji1901284

• Bessman NJ, Mathieu JRR, Renassia C, Zhou L, Fung TC, Fernandez KC, Austin C, Moeller JB, Zumerle S, Louis S, Vaulont S, Ajami NJ, Sokol H, Putzel GG, Arvedson T, Sockolow RE, Lakhal-Littleton S, Cloonan SM, Arora M, Peyssonnaux C, Sonnenberg GF. Dendritic cell-derived hepcidin sequesters iron from the microbiota to promote mucosal healing. Science. 2020 Apr 10;368(6487):186-189.

• O'Beirne SL, Kikkers SA, Oromendia C, Salit J, Rostmai MR, Ballman KV, Kaner RJ, Crystal RG, Cloonan SM. Alveolar Macrophage Immunometabolism and Lung Function Impairment in Smoking and Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2020 Mar 15;201(6):735-739.

• Zhang WZ, Rice MC, Hoffman KL, Oromendia C, Barjaktarevic I, Wells JM, Hastie AT, Labaki WW, Cooper CB, Comellas AP, Criner GJ, Krishnan JA, Paine Iii R, Hansel NN, Bowler RP, Barr RG, Peters SP, Woodruff PG, Curtis JL, Han MK, Ballman KV, Martinez FJ, Choi AM, Nakahira K, Cloonan SM, Choi ME. Association of urine mitochondrial DNA with clinical measures of COPD in the SPIROMICS cohort. JCI Insight. 2020 Feb 13;5(3).

• Aghapour M, Remels AHV, Pouwels SD, Bruder D, Hiemstra PS, Cloonan SM, Heijink IH. Mitochondria: at the crossroads of regulating lung epithelial cell function in chronic obstructive pulmonary disease. Am J Physiol Lung Cell Mol Physiol. 2020 Jan 1;318(1):L149-L164. 

2019

• Zhang WZ, Cloonan SM. To "Fe"ed or Not to "Fe"ed: Iron Depletion Exacerbates Emphysema Development in Murine Smoke Model. Am J Respir Cell Mol Biol. 2019 Nov 19. Am J Respir Cell Mol Biol. 2019 Nov 19.

• Chung KP, Hsu CL, Fan LC, Huang Z, Bhatia D, Chen YJ, Hisata S, Cho SJ, Nakahira K, Imamura M, Choi ME, Yu CJ, Cloonan SM, Choi AMK.Mitofusins regulate lipid metabolism to mediate the development of lung fibrosis. Nat Commun. 2019 Jul 29;10(1):3390.

• Najafinobar N, Venkatesan S, von Sydow L, Klarqvist M, Olsson H, Zhou XH, Cloonan SM, Malmberg P. ToF-SIMS mediated analysis of human lung tissue reveals increased iron deposition in COPD (GOLD IV) patients. Sci Rep. 2019 Jul 11;9(1):10060.

• Plataki M, Fan L, Sanchez E, Huang Z, Torres LK, Imamura M, Zhu Y, Cohen DE, Cloonan SM, Choi AM. Fatty acid synthase downregulation contributes to acute lung injury in murine diet-induced obesity. JCI Insight. 2019 Jul 9;5.

• Faner R, Morrow JD, Casas-Recasens S, Cloonan SM, Noell G, López-Giraldo A, Tal-Singer R, Miller BE, Silverman EK, Agustí A, Hersh CP. Do sputum or circulating blood samples reflect the pulmonary transcriptomic differences of COPD patients? A multi-tissue transcriptomic network META-analysis. Respir Res. 2019 Jan 8;20(1):5.

• Ward DM, Cloonan SM. Mitochondrial Iron in Human Health and Disease. Annu Rev Physiol. 2019 Feb 10;81:453-482.

• Zhang WZ, Butler JJ, Cloonan SM. Smoking-induced iron dysregulation in the lung. Free Radic Biol Med. 2019 Mar;133:238-247.

2018

• Pabón MA, Patino E, Bhatia D, Rojas-Quintero J, Ma KC, Finkelsztein EJ, Osorio JC, Malick F, Polverino F, Owen CA, Ryter SW, Choi AM, Cloonan SM, Choi ME. Beclin-1 regulates cigarette smoke-induced kidney injury in a murine model of chronic obstructive pulmonary disease. JCI Insight. 2018 Sep 20;3(18). pii: 99592.

• Ma KC, Schenck EJ, Siempos II, Cloonan SM, Finkelsztein EJ, Pabon MA, Oromendia C, Ballman KV, Baron RM, Fredenburgh LE, Higuera A, Lee JY, Chung CR, Jeon K, Yang JH, Howrylak JA, Huh JW, Suh GY, Choi AM. Circulating RIPK3 levels are associated with mortality and organ failure during critical illness. JCI Insight. 2018 Jul 12;3(13). pii: 99692.

• Racanelli AC, Kikkers SA, Choi AMK, Cloonan SM. Autophagy and inflammation in chronic respiratory disease. Autophagy. 2018;14(2):221-232.

2017

• Cloonan SM. Circulating Mitochondrial DNA as a Mechanism-based, Prognostic Biomarker for Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2017 Dec 15;196(12):1502-1504. 

• Cloonan SM, Mumby S, Adcock IM, Choi AMK, Chung KF, Quinlan GJ. The "Iron"-y of Iron Overload and Iron Deficiency in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2017 Nov 1;196(9):1103-1112. 

• Morrow JD, Zhou X, Lao T, Jiang Z, DeMeo DL, Cho MH, Qiu W, Cloonan S, Pinto-Plata V, Celli B, Marchetti N, Criner GJ, Bueno R, Washko GR, Glass K, Quackenbush J, Choi AM, Silverman EK, Hersh CP. Functional interactors of three genome-wide association study genes are differentially expressed in severe chronic obstructive pulmonary disease lung tissue. Sci Rep. 2017 Mar 13;7:44232.

2016

• Mizumura K, Cloonan S, Choi ME, Hashimoto S, Nakahira K, Ryter SW, Choi AM. Autophagy: Friend or Foe in Lung Disease? Ann Am Thorac Soc. 2016 Mar;13 Suppl 1:S40-7.

• Cloonan SM, Choi AM. Mitochondria in lung disease. J Clin Invest. 2016 Mar 1;126(3):809-20.

• Cloonan SM, Glass K, Laucho-Contreras ME, Bhashyam AR, Cervo M, Pabón MA, Konrad C, Polverino F, Siempos II, Perez E, Mizumura K, Ghosh MC, Parameswaran H, Williams NC, Rooney KT, Chen ZH, Goldklang MP, Yuan GC, Moore SC, Demeo DL, Rouault TA, D'Armiento JM, Schon EA, Manfredi G, Quackenbush J, Mahmood A, Silverman EK, Owen CA, Choi AM. Mitochondrial iron chelation ameliorates cigarette smoke-induced bronchitis and emphysema in mice. Nat Med. 2016 Feb;22(2):163-74.

2013-2015

• Cloonan SM, Elmes RB, Erby M, Bright SA, Poynton FE, Nolan DE, Quinn SJ, Gunnlaugsson T, Williams DC. Detailed Biological Profiling of a Photoactivated and Apoptosis Inducing pdppz Ruthenium(II) Polypyridyl Complex in Cancer Cells. J Med Chem. 2015 Jun 11;58(11):4494-505.

• Mizumura K, Cloonan SM, Nakahira K, Bhashyam AR, Cervo M, Kitada T, Glass K, Owen CA, Mahmood A, Washko GR, Hashimoto S, Ryter SW, Choi AM. Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD. J Clin Invest. 2014 Sep;124(9):3987-4003.

• Cloonan SM, Lam HC, Ryter SW, Choi AM. "Ciliophagy": The consumption of cilia components by autophagy. Autophagy. 2014 Mar;10(3):532-4. 

• [Lam HC, Cloonan SM], Bhashyam AR, Haspel JA, Singh A, Sathirapongsasuti JF, Cervo M, Yao H, Chung AL, Mizumura K, An CH, Shan B, Franks JM, Haley KJ, Owen CA, Tesfaigzi Y, Washko GR, Quackenbush J, Silverman EK, Rahman I, Kim HP, Mahmood A, Biswal SS, Ryter SW, Choi AM. Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction. J Clin Invest. 2013 Dec;123(12):5212-30.

• Nakahira K, Cloonan SM, Mizumura K, Choi AM, Ryter SW. Autophagy: a crucial moderator of redox balance, inflammation, and apoptosis in lung disease. Antioxid Redox Signal. 2014 Jan 20;20(3):474-94.

• Cloonan SM, Choi AM. Mitochondria: sensors and mediators of innate immune receptor signaling. Curr Opin Microbiol. 2013 Jun;16(3):327-38.

• Ryter SW, Cloonan SM, Choi AM.Autophagy: a critical regulator of cellular metabolism and homeostasis. Mol Cells. 2013 Jul;36(1):7-16

• Cloonan SM, Choi AM. Mitochondria: sensors and mediators of innate immune receptor signaling. Curr Opin Microbiol. 2013 Jun;16(3):327-38. doi: 10.1016/j.mib.2013.05.005.

• Ryter SW, Cloonan SM, Choi AM. Autophagy: a critical regulator of cellular metabolism and homeostasis. Mol Cells. 2013 Jul;36(1):7-16

Pre-2013

• Mizumura K, Cloonan SM, Haspel JA, Choi AMK. The emerging importance of autophagy in pulmonary diseases. Chest. 2012 Nov;142(5):1289-1299

• Constantin M, Choi AJ, Cloonan SM, Ryter SW. Therapeutic potential of heme oxygenase-1/carbon monoxide in lung disease. Int J Hypertens. 2012;2012:859235

• Breen JM, Clérac R, Zhang L, Cloonan SM, Kennedy E, Feeney M, McCabe T, Williams DC, Schmitt W. Self-assembly of hybrid organic-inorganic polyoxovanadates: functionalised mixed-valent clusters and molecular cages. Dalton Trans. 2012 Mar 14;41(10):2918-26.

• Cloonan SM, Choi AM. Mitochondria: commanders of innate immunity and disease? Curr Opin Immunol. 2012 Feb;24(1):32-40. 

• Elmes RB, Orange KN, Cloonan SM, Williams DC, Gunnlaugsson T. Luminescent ruthenium(II) polypyridyl functionalized gold nanoparticles; their DNA binding abilities and application as cellular imaging agents. J Am Chem Soc. 2011 Oct 12;133(40):15862-5.

• McNamara YM, Cloonan SM, Knox AJ, Keating JJ, Butler SG, Peters GH, Meegan MJ, Williams DC. Synthesis and serotonin transporter activity of 1,3-bis(aryl)-2-nitro-1-propenes as a new class of anticancer agents. Bioorg Med Chem. 2011 Feb 1;19(3):1328-48. 

• Elmes RB, Erby M, Cloonan SM, Quinn SJ, Williams DC, Gunnlaugsson T. Quaternarized pdppz: synthesis, DNA-binding and biological studies of a novel dppz derivative that causes cellular death upon light irradiation. Chem Commun (Camb). 2011 Jan 14;47(2):686-8. 

• Nathwani SM, Cloonan SM, Stronach M, Campiani G, Lawler M, Williams DC, Zisterer DM. Novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines, induce cell cycle arrest and apoptosis in prostate cancer cells. Oncol Rep. 2010 Dec;24(6):1499-507.

• Cloonan SM, Williams DC. The antidepressants maprotiline and fluoxetine induce Type II autophagic cell death in drug-resistant Burkitt's lymphoma. Int J Cancer. 2011 Apr 1;128(7):1712-23.

• Cloonan SM, Keating JJ, Corrigan D, O'Brien JE, Kavanagh PV, Williams DC, Meegan MJ. Synthesis and in vitro toxicity of 4-MTA, its characteristic clandestine synthesis byproducts and related sulfur substituted alpha-alkylthioamphetamines. Bioorg Med Chem. 2010 Jun 1;18(11):4009-31. 

• Cloonan SM, Drozgowska A, Fayne D, Williams DC. The antidepressants maprotiline and fluoxetine have potent selective antiproliferative effects against Burkitt lymphoma independently of the norepinephrine and serotonin transporters. Leuk Lymphoma. 2010 Mar;51(3):523-39. 

• Cloonan SM, Keating JJ, Butler SG, Knox AJ, Jørgensen AM, Peters GH, Rai D, Corrigan D, Lloyd DG, Williams DC, Meegan MJ. Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents. Eur J Med Chem. 2009 Dec;44(12):4862-88.

• Mulligan JM, Greene LM, Cloonan S, Mc Gee MM, Onnis V, Campiani G, Fattorusso C, Lawler M, Williams DC, Zisterer DM.Identification of tubulin as the molecular target of proapoptotic pyrrolo-1,5-benzoxazepines. Mol Pharmacol. 2006 Jul;70(1):60-70.